For now, Lee is predicting a 5-0 or 4-1 victory in his favor.
AlphaGo defeated a professional Go player for the first time in October, something that experts had predicted would take a decade. The match, described in a paper released in the journal Nature last month, marked a significant advance for development of artificial intelligence.
Lee, 32, said AlphaGo's October match showed the program was still a few levels lower than him. It has not had enough time to improve its skills.
"But if artificial intelligence continues to advance, in a year or two years, it will be really hard to guess the results," Lee said.
Computers have long surpassed humans in other games, including chess. But Go is considered the most challenging for artificial intelligence to master because of its intuitive nature and complexity.
Before AlphaGo, the Go community thought it would take a few generations for computers to match human players. So the October shut-out of the European champion was "truly shocking," said Park Chi-moon, vice president of the Korean Baduk Association.
The winner of the five-game match starting March 9 in Seoul will get a $1 million (roughly Rs. 6.8 crores) prize. If AlphaGo wins, the prize will be donated to charities, including UNICEF.
Demis Hassabis, CEO at AlphaGo developer Google DeepMind, said the program will enable smartphones to provide smarter help for people in the near future. Eventually, it will enable computers to help scientists solve some of the toughest real-world problems, such as disease analysis and climate modeling, he said.
Go originated in China more than 2,500 years ago. It involves two players who take turns putting markers on a checkerboard-like grid. The object is to take over more area on the board with the markers than one's opponent, and to capture the opponent's pieces by surrounding them.