The government said last year there were no legal barriers to the technology being tested and gave the go-ahead for vehicle trials to start on some local roads.
Finance minister George Osborne will announce plans on Wednesday to test vehicles on motorways and say the government will bring forward proposals to remove regulatory barriers to the technology, the Treasury said.
"Naturally we need to ensure safety, and that's what the trials we are introducing will test," Osborne said in a statement ahead of his annual budget presentation.
"If successful, we could see driverless cars available for sale and on Britain's roads, boosting UK jobs and productivity."
The market for autonomous driving is worth GBP 900 billion ($1.29 trillion) worldwide, according to the government, but needs to overcome legal obstacles including determining who would be responsible in the event of an accident.
Driverless car testing will be restricted to vehicles with a person present and able to take control should the need arise, Britain's Department for Transport has previously said.
On Friday, the top US safety agency said there were still significant legal hurdles to be cleared before self-driving cars without steering wheels and gas pedals could be sold in the United States.
Alphabet Inc unit Google wants to eventually be able to deploy fully autonomous vehicles without human controls, and major automakers are racing to develop vehicles that can drive themselves at least part of the time.
© Thomson Reuters 2016