Thrikutam was in charge of strategic sales, marketing and alliances, and president Pravin Rao will take up his portfolio, an Infosys spokeswoman said.
Infosys has lost at least 11 senior managers over the past year or so, as India's second-largest IT services exporter looks for a new chief executive.
The last exit was of president and board member B.G. Srinivas, who quit on May 29.
Reports speculated B G Srinivas may join another IT services firm as its chief executive and managing director.
"Srinivas will join as CEO and Managing Director (MD) of another listed entity. The announcement to this effect is likely to announced soon," sources in know of the development told PTI.
Srinivas, who was Infosys' highest-paid executive (annual compensation of Rs. 7.52 crore in FY14), led key portfolios like financial services, manufacturing and public services at the IT services firm.
His resignation will be effective June 10. Srinivas was considered to be among the top contenders for the job of CEO, replacing S D Shibulal, who retires on January 9, 2015.
Written with agency inputs