The cuts, expected to be announced during the company's third quarter earnings announcement this week, could impact more than 10 percent of the company's 30,000-person workforce, The Information reported, citing people inside and outside of the microchip maker.
The company has been under pressure from hedge fund Jana Partners to spin off its chip business from its highly profitable patent-licensing business.
The San Diego, California-based chipmaker may announce that it is considering that and other options - including returning more cash to shareholders, when it reports third-quarter results on Wednesday, sources told the Journal. However, there is no guarantee of such an announcement as the company's plans are in flux, they added.
The news comes after reports earlier on Monday that Qualcomm is preparing to lay off several thousand employees.
Qualcomm could not be immediately reached for comment outside regular U.S. working hours. Jana could not be reached for comment.
The company's shares were up about 3.2 percent in after-hours trading after closing at $63.79 on the Nasdaq on Monday.
© Thomson Reuters 2015